Keap1-dependent gene expression determined in the liver using conditional Keap1 knockout mice vs. genetic control mice

Build and Download Custom Datasets

refine.bio helps you build ready-to-use datasets with normalized transcriptome data from all of the world’s genetic databases.

GSE11287

Mus musculus

6 Downloadable Samples

Affymetrix Mouse Genome 430 2.0 Array (mouse4302)

Submitter Supplied Information

Description

To compare hepatic gene expression in conditional Keap1 knockout (Alb-Cre:Keap1(flox/-)) and genetic control mice. Disruption of Keap1-mediated repression of Nrf2 signaling was expected to result in increased expression of Nrf2-regulated genes.

PubMed ID

18417483

Publication Title

Genetic or pharmacologic amplification of nrf2 signaling inhibits acute inflammatory liver injury in mice.

Total Samples

Submitter’s Institution

Johns Hopkins Bloomberg School of Public Health

Authors

Osburn WO, Yates MS, Dolan PD, Chen S, Liby KT, Sporn MB, Taguchi K, Yamamoto M, Kensler TW

Source Repository

Gene Expression Omnibus (GEO)

No rows found