Identification of genes involved in cell death induced by sodium fluoride in rat oral epithelial cells

Although an appropriate range of fluoride is thought to be safe and effective, excessive fluoride intake results in toxic effects in either hard tissues of teeth and skeleton or soft tissues of kidney, lung and brain. It is also well known that fluoride at a millimolar range elicits the complex cellular responses such as enzyme activity, signal transduction and apoptosis in many kinds of cells. However, its toxic effects are still unclear.

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Tabuchi Y, Yunoki T, Hoshi N, Suzuki N, Kondo T