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Accession IconGSE80490

A paradoxical tumor suppressor role for the Rac1 exchange factor Vav1 in early cortical T cell acute lymphoblastic leukemia

Organism Icon Mus musculus
Sample Icon 15 Downloadable Samples
Technology Badge Icon Affymetrix Mouse Gene 1.0 ST Array (mogene10st)

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Robles-Valero et al. report a tumor suppression role for the otherwise oncogenic Vav1 Rho GEF. This paradoxical action is mediated by the catalysis-independent buffering of Notch1 signaling in immature T cells.
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