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Accession IconGSE85190

Gene expression profile (GEP) of MAF-overexpressing CD34+ hematopoietic progenitor cells (HPCs)

Organism Icon Homo sapiens
Sample Icon 9 Downloadable Samples
Technology Badge Icon Affymetrix Human Genome U219 Array (hgu219)

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Description
Primary Myelofibrosis (PMF) is a myeloproliferative neoplasm characterized by hyperplastic megakaryopoiesis and myelofibrosis. Through a gene expression profile (GEP) study we recently highlighted the MAF upregulation in PMF versus healthy donor (HD) CD34+ hematopoietic progenitor cells (HPCs). To shed some light into the role of MAF in PMF pathogenesis, here we unravelled the effects of the overexpression of MAF in HPCs forcing its expression in HPCs.
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