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Accession IconSRP066786

Effect of PD-1 immune checkpoint in Alzheimer''s disease transgenic mice

Organism Icon Mus musculus
Sample Icon 25 Downloadable Samples
Technology Badge IconNextSeq 500

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Description
We examined the brain''s choroid plexus and myeloid cell populations isolated from the brain of 5XFAD Alzheimer''s disease transgenic mice following PD-1 blockade Overall design: Choroid plexus samples and myeloid cell populations were isolated from the brain of 5XFAD mice following PD-1 blockade, and sequenced. For choroid plexus samples, 5 mice were treated with anti-PD-1, 5 with IgG control, and 4 were left untreated. For the myeloid cells samples, myeloid cells sorted from the brains of 5XFAD mice according to a gating strategy that seperate microglia (CD11b+CD45-low) and monocytes-derived macrophages (CD11b+CD45-high).
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25
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