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Accession IconSRP075208

SOX7 supresses the expression of RUNX1 target genes during EHT

Organism Icon Mus musculus
Sample Icon 96 Downloadable Samples
Technology Badge IconNextSeq 500

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Description
The molecular mechanisms regulating endothelial to hematopoietic transition (EHT) of hemogenic endothelium (HE) are poorly understood. Here we profile the transcriptional changes resulting from SOX7 overexpression during EHT Overall design: FLK1+ cells were sorted from day 3.5 iSox7 EBs and cultured in liquid blast media for 48hours. Dox was added for 6, 12 and 24 hours to induce SOX7 expression, before samples were harvested for RNAseq.
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96
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