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Accession IconSRP132194

Differential expression in wild type and mutant HAP1 cells [RNA-seq I]

Organism Icon Homo sapiens
Sample Icon 41 Downloadable Samples
Technology Badge IconIllumina HiSeq 2500

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Description
using RNA-seq we characterized gene expression changes occuring upon knockout of BAP1, ASXL1, ASXL2, ASXL1/2 or Polycomb genes RING1B and EZH2. We also investigated the response to retinoic acid treatment in wild-type and BAP1 KO cells. Overall design: Examination of transcript abundance in wild-type HAP1 cells and in 9 different HAP1-mutated cell lines as well as upon retinoic acid treatment in wild-type and BAP1 KO cells. Two biological replicated were performed for each condition.
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44
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